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The Role of C-Abl in TNF-α Induced PARP-1 Activation and Gene Expression

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The Role of C-Abl in TNF-α Induced PARP-1 Activation and Gene Expression
论文目录
 
ABSTRACT第1-9页
ABBREVIATIONS第9-12页
SECTION 1: Introduction第12-26页
    1.1. poly(ADP-ribosylation)第14-15页
    1.2. PARP-1 structure第15-17页
      1.2.1. The DNA-Binding Domain (DBD)第16页
      1.2.2. The Automodification domain (AMD)第16-17页
      1.2.3. The Catalytic domain (CD)第17页
    1.3. The mechanisms of PARP-1 activation in proinflammatory gene expression第17-19页
      1.3.1. DNA-Dependent PARP-1 Activation第17-18页
      1.3.2. DNA-Independent PARP-1Activation第18-19页
    1.4. c-Abl第19-20页
    1.5. Structure and subcellular localization of c-Abl第20页
    1.6. Activation of c-Abl第20-24页
      1.6.1. Activation of Abl by SH3 Domain Ligands第21-22页
      1.6.2. Activation of Abl by SH2 Domain Ligands第22-23页
      1.6.3. Activation of Abl by phosphorylation第23-24页
    1.7. Interacting proteins of c-Abl第24-25页
    1.8. Cellular functions of c-Abl第25-26页
SECTION 2: Material and Methods第26-28页
    2.1. Antibodies and reagents第26页
    2.2. Cell culture Treatment第26页
    2.3. RNA isolation and Reverse transcription–polymerase chain reaction第26-27页
    2.4. Immunoprecipitation assay第27页
    2.5. Immunoblotting第27-28页
SECTION 3: Results第28-33页
    3.1. TNF-α induced protein PARylation level第28页
    3.2. Inhibition of c-Abl reduced PARylation第28-29页
    3.3. TNF-α induced pro-inflammatory gene expression第29-30页
    3.4. Inhibition of c-Abl reduced pro-inflammatory gene expression第30-31页
    3.5. TNF-α induced binding of c-Abl with PARP-1第31页
    3.6. c-Abl is required for tyrosine phosphorylation of PARP-1 in response to TNF- αstimulation第31-33页
SECTION 4: Discussion第33-35页
SECTION 5: Conclusion第35-36页
References第36-43页
Acknowledgement第43页

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